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A few tests of hind limb withdrawal to thermal, chilly and mechanical stimuli were utilized in this review. Each take a look at was repeated on both equally the operated hind paw and the contralateral hind paw with all sensory screening executed by a ‘blinded' investigator.
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The analgesic properties of your artificial cannabinoid WIN55,212-2 were being investigated inside of a design of neuropathic ache. In male Wistar rats, bilateral hind limb withdrawal thresholds to cold, mechanical and noxious thermal stimuli had been calculated.
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A further breakthrough from the elucidation of cannabinoid pharmacology arrived in 1988 with the invention of the cannabinoid receptor in rat brain (CB1, Devane et al